CO-LOADED LAPATINIB/PAB BY FERRITIN NANOPARTICLES ELIMINATED ECM-DETACHED CLUSTER CELLS VIA MODULATING EGFR IN TRIPLE-NEGATIVE BREAST CANCER

Co-loaded lapatinib/PAB by ferritin nanoparticles eliminated ECM-detached cluster cells via modulating EGFR in triple-negative breast cancer

Abstract Cancer stem cell (CSC) cluster of triple-negative breast cancer (TNBC) is suggested to be responsible for therapy resistance, metastatic process and cancer recurrence, yet the sensitivity of CSC clusters of TNBC to ferroptosis remains elusive in a great measure.Current research revealed that epidermal growth factor receptor (EGFR) Dildo Se

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Intra-trackway morphological variations due to substrate consistency: the El Frontal dinosaur tracksite (Lower Cretaceous, Spain).

An ichnological and sedimentological study of the El Frontal dinosaur tracksite (Early Cretaceous, Cameros basin, Soria, Spain) highlights the pronounced intra-trackway variation found in track morphologies of four theropod trackways.Photogrammetric 3D digital models revealed various and distinct intra-trackway morphotypes, which reflect changes in

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THE INVESTIGATION OF BURNUP CHARACTERISTICS USING THE SERPENT MONTE CARLO CODE FOR A SODIUM COOLED FAST REACTOR

In this research, we investigated the burnup characteristics and the conversion of fertile 232Th Coconut Supplements into fissile 233U in the core of a Sodium-Cooled Fast Reactor (SFR).The SFR fuel assemblies were designed for burning 232Th fuel (fuel pin 1) and 233U fuel (fuel pin 2) and include mixed minor actinide compositions.Monte Carlo simula

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